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In the total population and treatment-nave patients, the HBsAg loss rates at week 48 were 24.7% (72/291) and 26.6% (49/184) and HBeAg loss rates were 19.8% (50/252) and 18.3% (31/169) in the combination therapy group, whereas no patients in the NA monotherapy group achieved any of above responses (Figure 1A)